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Premier League injury update as crucial London derby headlines Matchday 28

Premier League clubs return to action this weekend as we head into the twilight of an enthralling 2025/26 campaign.

There’s still plenty to play for on both ends of the Premier League table, although Burnley and Wolverhampton Wanderers already have their fates set in stone.

However, several eye-catching fixtures could shake up the Premier League after Matchday 28.

The Emirates Stadium forms the backdrop for this weekend’s headline fixture as Arsenal host London rivals Chelsea on Sunday.

The Blues will relish the opportunity to scupper Arsenal’s title hopes, but they have failed to get the better of them in three attempts already this season.

Fans will also be keeping an eye on Craven Cottage, where Fulham host Tottenham Hotspur in Igor Tudor’s second Premier League outing as interim manager.

It’ll be interesting to see how quickly he can get his message across, particularly after last weekend’s harsh reality check against Arsenal.

West Ham United will also be desperate to pick up points despite facing an uphill task against Liverpool at Anfield, while Nottingham Forest visit Brighton & Hove Albion as the battle for survival heats up.

Injuries, suspensions and late fitness doubts will play a major role in deciding how teams line up and perform this weekend, so we’ve highlighted all the latest injury news for each club ahead of Matchday 28’s fixtures.

Wolverhampton Wanderers vs Aston Villa

Wolverhampton Wanderers

Out: Leon Chiwome (knee), Hwang Hee-Chan (calf)

Suspended: Ladislav Krejci

Aston Villa

Out: Boubacar Kamara (knee), John McGinn, Youri Tielemans (ankle), Alysson (knock), Harvey Elliott (knock), Andres Garcia (hamstring)

Bournemouth vs Sunderland

Bournemouth

Out: Ben Gannon-Doak (hamstring), Matai Akinmboni (muscle), Justin Kluivert (knee), Julio Soler (hamstring), Lewis Cook (hamstring)

Sunderland

Out: Bertrand Traore (knee), Reinildo (knee), Romaine Mundle (knock), Dennis Cirkin (knock)

Doubtful: Nordi Mukiele, Djiamgone Jocelin Ta Bi (ankle), Brian Brobbey (knock), Granit Xhaka

Burnley vs Brentford

Burnley

Out: Connor Roberts (knock), Jordan Beyer (knee), Zeki Amdouni (knee), Josh Cullen (knee), Mike Tresor (knock), Axel Tuanzebe (Achilles), Armando Broja (knock)

Brentford

Out: Antoni Milambo (knee), Fabio Carvalho (knee), Josh Dasilva (knee)

Liverpool vs West Ham United

Liverpool

Out: Wataru Endo (foot), Alexander Isak (ankle), Giovanni Leoni (knee), Stefan Bajcetic (hamstring), Conor Bradley (knee), Jayden Danns (hamstring)

Doubtful: Florian Wirtz (back), Jeremie Frimpong (hamstring)

West Ham United

Out: Pablo Felipe (calf), Lukasz Fabianski (back)

Suspended: Freddie Potts

Newcastle United vs Everton

Newcastle

Out: Bruno Guimaraes (hamstring), Lewis Miley (knock), Emil Krafth (knee), Fabian Schar (ankle), Valentino Livramento (hamstring)

Everton

Out: Jack Grealish (foot), Mark Travers (finger), Charly Alcaraz

Leeds United vs Manchester City (Saturday, 6:30pm)

Leeds United

Out: Noah Okafor (hamstring)

Doubtful: Gabriel Gudmundsson (illness)

Manchester City

Out: Mateo Kovacic (ankle), Josko Gvardiol (shin)

Doubtful: Max Alleyne (knock), Jeremy Doku (calf)

Brighton & Hove Albion vs Nottingham Forest

Brighton & Hove Albion

Out: Yasin Ayari (shoulder), Adam Webster (knee), Solly March (knee), Stefanos Tzimas (knee)

Nottingham Forest

Out: Chris Wood (knee), John Victor (knock), Matz Selz (groin), Nicolo Savona (knee), Willy Boly (knee)

Fulham vs Tottenham Hotspur

Fulham

Out: Kevin, Antonee Robinson (ankle)

Doubtful: Sasa Lukic (hamstring), Samuel Chukwueze (calf)

Tottenham Hotspur

Out: Wilson Odobert (ACL), Destiny Udogie (hamstring), Dejan Kulusevski (knee), James Maddison (knee), Mohammed Kudus (thigh), Rodrigo Bentancur (hamstring), Ben Davies (ankle), Lucas Bergvall (ankle)

Manchester United vs Crystal Palace

Manchester United

Out: Patrick Dorgu (muscle), Matthijs de Ligt (back), Mason Mount (knock), Lisandro Martinez (calf)

Crystal Palace

Out: Maxence Lacroix (adductor), Jean-Philippe Mateta (knee), Jefferson Lerma (hamstring), Eddie Nketiah (hamstring), Cheick Doucoure (knee)

Arsenal vs Chelsea

Arsenal

Out: Mikel Merino (foot), Maz Dowman (ankle)

Doubtful: Kai Havertz (hamstring), Ben White (knock)

Chelsea

Out: Jamie Gittens (hamstring), Levi Colwill (knee), Filip Jorgensen (knock)

Doubtful: Marc Cucurella (hamstring), Estevao (hamstring)

Suspended: Wesley Fofana

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