Premier League clubs return to action this weekend as we head into the twilight of an enthralling 2025/26 campaign.
There’s still plenty to play for on both ends of the Premier League table, although Burnley and Wolverhampton Wanderers already have their fates set in stone.
However, several eye-catching fixtures could shake up the Premier League after Matchday 28.
The Emirates Stadium forms the backdrop for this weekend’s headline fixture as Arsenal host London rivals Chelsea on Sunday.
The Blues will relish the opportunity to scupper Arsenal’s title hopes, but they have failed to get the better of them in three attempts already this season.
Fans will also be keeping an eye on Craven Cottage, where Fulham host Tottenham Hotspur in Igor Tudor’s second Premier League outing as interim manager.
It’ll be interesting to see how quickly he can get his message across, particularly after last weekend’s harsh reality check against Arsenal.
West Ham United will also be desperate to pick up points despite facing an uphill task against Liverpool at Anfield, while Nottingham Forest visit Brighton & Hove Albion as the battle for survival heats up.
Injuries, suspensions and late fitness doubts will play a major role in deciding how teams line up and perform this weekend, so we’ve highlighted all the latest injury news for each club ahead of Matchday 28’s fixtures.
Wolverhampton Wanderers vs Aston Villa

Wolverhampton Wanderers
Out: Leon Chiwome (knee), Hwang Hee-Chan (calf)
Suspended: Ladislav Krejci
Aston Villa
Out: Boubacar Kamara (knee), John McGinn, Youri Tielemans (ankle), Alysson (knock), Harvey Elliott (knock), Andres Garcia (hamstring)
Bournemouth vs Sunderland

Bournemouth
Out: Ben Gannon-Doak (hamstring), Matai Akinmboni (muscle), Justin Kluivert (knee), Julio Soler (hamstring), Lewis Cook (hamstring)
Sunderland
Out: Bertrand Traore (knee), Reinildo (knee), Romaine Mundle (knock), Dennis Cirkin (knock)
Doubtful: Nordi Mukiele, Djiamgone Jocelin Ta Bi (ankle), Brian Brobbey (knock), Granit Xhaka
Burnley vs Brentford

Burnley
Out: Connor Roberts (knock), Jordan Beyer (knee), Zeki Amdouni (knee), Josh Cullen (knee), Mike Tresor (knock), Axel Tuanzebe (Achilles), Armando Broja (knock)
Brentford
Out: Antoni Milambo (knee), Fabio Carvalho (knee), Josh Dasilva (knee)
Liverpool vs West Ham United

Liverpool
Out: Wataru Endo (foot), Alexander Isak (ankle), Giovanni Leoni (knee), Stefan Bajcetic (hamstring), Conor Bradley (knee), Jayden Danns (hamstring)
Doubtful: Florian Wirtz (back), Jeremie Frimpong (hamstring)
West Ham United
Out: Pablo Felipe (calf), Lukasz Fabianski (back)
Suspended: Freddie Potts
Newcastle United vs Everton

Newcastle
Out: Bruno Guimaraes (hamstring), Lewis Miley (knock), Emil Krafth (knee), Fabian Schar (ankle), Valentino Livramento (hamstring)
Everton
Out: Jack Grealish (foot), Mark Travers (finger), Charly Alcaraz
Leeds United vs Manchester City (Saturday, 6:30pm)

Leeds United
Out: Noah Okafor (hamstring)
Doubtful: Gabriel Gudmundsson (illness)
Manchester City
Out: Mateo Kovacic (ankle), Josko Gvardiol (shin)
Doubtful: Max Alleyne (knock), Jeremy Doku (calf)
Brighton & Hove Albion vs Nottingham Forest

Brighton & Hove Albion
Out: Yasin Ayari (shoulder), Adam Webster (knee), Solly March (knee), Stefanos Tzimas (knee)
Nottingham Forest
Out: Chris Wood (knee), John Victor (knock), Matz Selz (groin), Nicolo Savona (knee), Willy Boly (knee)
Fulham vs Tottenham Hotspur

Fulham
Out: Kevin, Antonee Robinson (ankle)
Doubtful: Sasa Lukic (hamstring), Samuel Chukwueze (calf)
Tottenham Hotspur
Out: Wilson Odobert (ACL), Destiny Udogie (hamstring), Dejan Kulusevski (knee), James Maddison (knee), Mohammed Kudus (thigh), Rodrigo Bentancur (hamstring), Ben Davies (ankle), Lucas Bergvall (ankle)
Manchester United vs Crystal Palace

Manchester United
Out: Patrick Dorgu (muscle), Matthijs de Ligt (back), Mason Mount (knock), Lisandro Martinez (calf)
Crystal Palace
Out: Maxence Lacroix (adductor), Jean-Philippe Mateta (knee), Jefferson Lerma (hamstring), Eddie Nketiah (hamstring), Cheick Doucoure (knee)
Arsenal vs Chelsea

Arsenal
Out: Mikel Merino (foot), Maz Dowman (ankle)
Doubtful: Kai Havertz (hamstring), Ben White (knock)
Chelsea
Out: Jamie Gittens (hamstring), Levi Colwill (knee), Filip Jorgensen (knock)
Doubtful: Marc Cucurella (hamstring), Estevao (hamstring)
Suspended: Wesley Fofana
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