Raphael Varane may be reinstated alongside Lisandro Martinez, although he may not be fit to last the entire game for United.
Aaron Wan-Bissaka and Diogo Dalot are nailed-on starters from the full-back position.
Erik ten Hag could stick with the midfield combination of Sofyan Amrabat and Kobbie Mainoo, who have started the last few league games together.
Casemiro has been United’s regular in the number six position, but the club have had multiple training sessions this week with the Brazilian absent from the starting XI.
It would be a huge call from Ten Hag, considering Amrabat was far from his best against Brighton & Hove Albion where he struggled against the high press.
Marcus Rashford should be reinstated on the left flank. He likes the big occasion and has scored in six Manchester derbies.
This would mean Alejandro Garnacho moving to the right wing. The Argentine ace is set to make his 38th consecutive start of the campaign for United.
Bruno Fernandes is expected to start in his customary number 10 role with Rasmus Hojlund leading the line. The Dane has scored in his last two appearances as a substitute.
Amad Diallo and Scott McTominay will drop to the bench after starting recent games.
How Man Utd could line up against Man City
Stats from Transfermarkt.com.
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