Wednesday are yet to win a league game this season, and Munoz’s final game in charge was the Tuesday night defeat to West Bromwich Albion, marking the club’s eighth loss in ten games.
Wednesday suffered an embarrassing 3-0 defeat to Sunderland last weekend, further piling the pressure on the already beleaguered Munoz.
They have picked up just two points from their opening ten games and are already seven points adrift from safety.
Munoz only arrived at Hillsborough this summer as the club sought a replacement for Darren Moore, who departed despite leading the Owls to promotion from League One through the play-offs.
Throughout his tumultuous tenure, the 43-year-old’s only triumph came in a penalty shoot-out against League Two side Stockport County in the first round of the Carabao Cup.
However, Wednesday failed to make it past the second round as they were eliminated on penalties by fourth-tier side Mansfield Town.
Wednesday have confirmed that they have begun the process of appointing a successor to Munoz as the Yorkshire outfit strives to retain their status in the Championship.
“Sheffield Wednesday have parted company with Xisco Munoz, who leaves Hillsborough with immediate effect,” the statement read.
“Xisco’s backroom staff – Miguel Muñoz, Miguel Gomila, Roberto Cuesta Roman and Antonello Brambilla – also depart the club.
“Under-21s manager Neil Thompson will take the team for Saturday’s home game against Huddersfield Town in the Championship.
“The Owls would like to thank Xisco and his staff for their services and wish them well for the future.”
Interim manager Thompson will be eager to kick off his temporary leadership with a strong performance against the Terriers.
He will have an eye on securing the job permanently if he can steer the club away from danger.
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