The former West Ham United captain complained about a back problem, and manager Mikel Arteta brought him off.
The injury reportedly got worse overnight. It is restricting Rice’s movement, sparking fears that the Gunners may be without him for a while.
The 24-year-old joined Arsenal this summer in a deal worth around £105 million. He has been one of the bright parts of their campaign, producing terrific performances in every game.
The England international is now ongoing tests to determine the extent of the injury.
Arsenal will face Brentford in the League Cup on Wednesday, and Rice is unlikely to be in the squad.
It is unclear whether he will be available for the league game at Bournemouth on Saturday and next week’s Champions League game against Ligue 1 side RC Lens.
Arsenal hope that Rice will return for their Super Sunday clash with Manchester City on October 8.
The match with City could go a long way in determining where the Premier League title will go this season.
The pair led the title race last season, but Liverpool are rejuvenated and look set to challenge again.
Arsenal need all hands on deck as they push for their first title in 19 years and will hope to have Rice fit and raring to go.
Apart from Rice, Arsenal duo Leandro Trossard and Gabriel Martinelli are also out with injury problems. However, they are both expected to be fit to face City.
Thomas Partey continues to recover from his groin injury and is expected to return after the October international break.
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