The Red Devils would be dealt a massive blow if Rashford misses the game.
The club are searching for their first trophy since 2017 and his absence could prove costly.
They have been drawn against Real Betis in the round of 16 of the Europa League. However, their hard-fought 2-1 victory on Thursday night may have come at a cost.
Rashford has scored 24 goals and claimed six assists for Man United this term.