Liverpool have one foot in the Champions League quarter-finals, but Inter Milan will hope to overturn a 2-0 first-leg deficit at Anfield on Tuesday.
Two late goals from Roberto Firmino and Mohamed Salah handed the Reds an all-important first-leg win at Giuseppe Meazza.
Although Liverpool look to be on course to reach the Champions League quarter-finals for the fourth time in five seasons, there is no room for complacency in the Merseyside camp.
Liverpool vs Inter, along with other Champions League matches this midweek, are available to watch via live football streams.
Sadio Mane was on the scoresheet as Liverpool grabbed a crucial 1-0 Premier League triumph over West Ham United at the weekend, taking their unbeaten run in all competitions to 15 (W13, D2).
The aforementioned first-leg success saw the Reds become only the second side in the Champions League history to beat both Milan clubs in a single season.
However, Liverpool can ill-afford to underestimate the reigning Serie A champions, especially considering they have lost three of their last eight home European fixtures against Italian visitors (W4, D1).
After navigating his team to all seven Champions League victories this season, Jurgen Klopp is on the cusp of becoming the eighth manager to rack up 50 wins in the competition.
Inter got their stuttering Serie A title defence back on track last Friday with an overwhelming 5-0 triumph over basement boys Salernitana, ending a run of five competitive matches without winning (D3, L2).
It had taken the Nerazzurri three consecutive failed attempts to make it out of the Champions League group phase, but the round of 16 could be the end of the road for Simone Inzaghi’s side.
In addition to losing four of their last six Champions League last-16 ties, Inter have suffered eliminations in five of eight two-legged knock-out engagements after losing the first leg at home.
Their recent European record away to English clubs does not offer much comfort to the Serie A giants either, as they have lost six of their last seven such fixtures (W1).
Joel Matip, Thiago Alcantara and Firmino all have the question marks hanging over their heads, but other than them, Klopp will have his remaining players fit and ready for this clash.
Apart from suspended Nicolo Barella, Inter coach Inzaghi should have all of his star performers available for this trip, with marquee January signing Robin Gosens in contention to make his Champions League debut for his new side.
Liverpool Potential Starting XI:
(4-3-3): Alisson; Trent Alexander-Arnold, Ibrahima Konate, Virgil van Dijk, Andy Robertson; Jordan Henderson, Fabinho, Naby Keita; Mohamed Salah, Diogo Jota, Luis Diaz.
Inter Milan Potential Starting XI:
(3-5-2): Samir Handanovic; Mmilan Skriniar, Stefan de Vrij, Alessandro Bastoni; Denzel Dumfries, Arturo Vidal, Marcelo Brozovic, Hakan Calhanoglu, Robin Gosens; Edin Dzeko, Lautaro Martinez.
Liverpool vs Inter Milan Prediction
Inter will have a mountain to climb at Anfield, where they succumbed to a clear-cut 2-0 defeat in their most recent Champions League visit back in 2008.
By contrast, Liverpool have yet to lose a single home match in any competition this term (W18, D5), including seven consecutive wins in the build-up to this game.
Anfield has been a fortress this season, and we expect Salah and co to keep it that way.
Liverpool 2-1 Inter Milan.
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